HDAC3

組蛋白在轉錄調控、細胞周期進展和發育事件中起著關鍵作用。組蛋白乙酰化/去乙酰化改變染色體結構並影響轉錄因子對dna的獲取。該基因編碼的蛋白屬於組蛋白去乙酰化酶/acuc/apha傢族。它具有組蛋白脫乙酰酶活性，與啟動子結合時抑制轉錄。它可能通過與鋅指轉錄因子yy1結合參與轉錄調控。這種蛋白還可以下調p53的功能，從而調節細胞的生長和凋亡。該基因被認為是一種潛在的腫瘤抑制基因。[由RefSeq提供，2008年7月]
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]