GSTT1

由該基因編碼的蛋白質，谷胱甘肽s-轉移酶（gst）θ1（gstt1）是一個蛋白質超傢族的成員，它催化還原型谷胱甘肽與多種親電和疏水化合物的結合。人類gst可分為五大類：alpha、mu、pi、theta和zeta。theta類包括gstt1、gstt2和gstt2b，gstt1和gstt2/gstt2b具有55%的氨基酸序列同源性，可能在人類致癌過程中起作用。gstt1基因是單倍型特異性的，38%的人群中沒有gstt1基因。該基因的選擇性剪接導致多個轉錄變體。[由RefSeq提供，2015年9月]
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]