NR4A3

這個基因編碼類固醇甲狀腺激素視黃醇受體超傢族的一個成員編碼的蛋白質可以作為轉錄激活劑。該蛋白能有效結合ngfi-b反應元件（nbre）。三種不同的骨外黏液樣軟骨肉瘤（emcs）是該基因與其他基因相互易位的結果。易位斷點與核受體亞傢族4，A組，成員3（9號染色體上）和尤因肉瘤斷點區域1（22號染色體上）、RNA聚合酶II、tata-box結合蛋白相關因子、68-kD（17號染色體上）或轉錄因子12（15號染色體上）有關。已發現該基因編碼不同亞型的多個轉錄變體。[由RefSeq提供，2010年3月]
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]