LZTS1

該基因編碼一種在正常組織中廣泛表達的腫瘤抑制蛋白在葡萄膜黑色素瘤中，這種蛋白在快速轉移和轉移的腫瘤細胞中表達沉默，但在緩慢轉移或非轉移的腫瘤細胞中表達正常該蛋白可能通過與cdk1/cyclinb1復合物相互作用在細胞周期調控中發揮作用。該基因位於染色體8p22區8p臂雜合性缺失（loh）是多種癌癥的共同特征。[由RefSeq提供，2009年11月]
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]